Asociación entre la salud oral y el deterioro cognitivo leve en adultos mayores

Introducción: En la medida que se incrementa la población de adultos mayores, aumenta la prevalencia, aumenta la prevalencia del deterioro cognitivo. Recientemente, se ha introducido la mala salud oral entre los factores de riesgo potenciales. Objetivo: Determinar la asociación entre la salud oral y el deterioro cognitivo leve en adultos mayores de una comunidad de la provincia de Santiago de Cuba. Métodos: Se realizó un estudio observacional, analítico y retrospectivo, de tipo casos y controles en el período comprendido entre enero y julio del año 2023. La población de estudio estuvo constituida por 257 adultos mayores que vivían en esta comunidad, de los cuales se escogieron 40 casos con diagnóstico de deterioro cognitivo leve, según los criterios de Petersen. Se seleccionaron tres controles por cada caso, 120 adultos mayores con aproximadamente las mismas características que el caso. Se precisó la fuerza de asociación de cada factor de riesgo. Resultados: Se halló una asociación significativa entre padecer deterioro cognitivo leve y presentar un número de 1 a 9 dientes. El dolor oral se presentó con mayor frecuencia en el 72,5 % de los casos. No recordar la última visita al estomatólogo fue causa de deterioro cognitivo leve en el 42,5 %. Cepillarse irregularmente se asoció 4,1 veces más con el riesgo de desarrollar esta afección. Conclusiones : Existe una asociación entre la salud oral y el deterioro cognitivo leve en los adultos mayores. Tener menos dientes y referir dolor oral fueron factores de riesgo importantes para presentar deterioro cognitivo. La visita al estomatólogo y el cepillado de dientes irregular influyeron negativamente en la enfermedad. Sin embargo, el uso de prótesis dentales fue un factor protector para el deterioro cognitivo leve.

Introduction: Along with the increase in the population of older adults, the prevalence of cognitive impairment is increasing. Recently, poor oral health has been introduced among potential risk factors. Objective: To determine the association between oral health and mild cognitive impairment in older adults in a community in the province of Santiago de Cuba. Methods: An observational, analytical and retrospective case-control study was carried out from January to July 2023. The study population consisted of 257 older adults living in this community, from which 40 cases were selected with a diagnosis of mild cognitive impairment, according to Petersen's criteria. Three controls were selected for each case, 120 older adults with approximately the same characteristics as the case. The strength of association of each risk factor was determined. Results: A significant association was found between having mild cognitive impairment and having 1 to 9 teeth. Oral pain was more frequent in 72.5% of the cases. Not remembering the last visit to the dentist was a cause of mild cognitive impairment in 42.5 %. Irregular brushing was 4.1 times more associated with the risk of developing this condition. Conclusions: There is an association between oral health and mild cognitive impairment in older adults. Having fewer teeth and reporting oral pain were important risk factors for cognitive impairment. Visiting the dentist and irregular tooth brushing had a negative influence on the disease. However, the use of dental prosthetics was a protective factor for mild cognitive impairment.

Aplasia cutis congénita: a propósito de un caso / Aplasia cutis congenita: case report / Aplasia congênita da cútis: relato do caso

La aplasia cutis congénita es una patología rara caracterizada por la ausencia de desarrollo de piel. Aunque puede localizarse en diferentes áreas del cuerpo, mayormente afecta el cuero cabelludo y puede extenderse a tejidos subyacentes. Presentamos aquí un caso clínico que se destaca por la extensión de la lesión. Se incluye la descripción del tratamiento y seguimiento del paciente.

Aplasia Cutis Congenita is a rare pathology characterized by the absence of development of the epidermis, and even though it can compromise any area of the body, it usually affects the scalp and it can be extended to the underlying tissues. We present a particular case due to the lesion size. It includes treatment description and follow-up.

A Aplasia Congênita da Cútis é uma patologia rara caracterizada pela ausência de desenvolvimento das epidermes, e embora possa se localizar em diferentes áreas do corpo, acomete principalmente o couro cabeludo e pode se espalhar para os tecidos subjacentes. Apresentamos aqui um caso clínico que se destaca pela extensão da lesão. Incluímos a descrição do tratamento e acompanhamento do paciente.

Efecto de la dibucaína sobre la SERCA del músculo pterigoideo interno / Drug action of dibucaine on the SERCA from medial pterygoid muscle

Objetivo: Determinar el efecto del anestésico local di-bucaína sobre las principales isoformas de la SERCA (calcio ATPasa de retículo sarco-endoplásmico) pre-sentes en músculo pterigoideo interno. Métodos: Se aislaron por centrifugación diferencial membranas de retículo sarcoplásmico de pterigoideo interno de conejo neozelandés macho (n=5). Se separaron las isoformas SERCA1a, 2a y 2b por cromatografía de afinidad. Se determinó in vitro la actividad enzimá-tica en presencia de diferentes concentraciones de dibucaína (0-90 mM) por el método de Fiske y Subba-row, realizando 5 experimentos por duplicado y en paralelo para cada isoforma. Se calculó la media y ES de la CI50 (mM) del anestésico para cada isofor-ma y éstas se compararon por ANOVA de una vía (p<0,05), y prueba Student-Newman-Keuls de com-paraciones múltiples. Resultados: Dibucaína inhibió la actividad enzimática en función de su concentra-ción en las tres isoformas en estudio. Las CI50 fueron: SERCA1a 20,02 ± 0,64 mM, SERCA2a 15,03 ± 0,52 mM y SERCA2b 16,00 ± 0,51 mM y resultaron signi-ficativamente diferentes (F2,27 = 11,08, p<0,001). La prueba post hoc identificó diferencias significativas entre SERCA1a y 2a, 1a y 2b. El efecto inhibitorio re-sultó significativamente mayor sobre las isoformas 2a y 2b, cuya presencia es sustancialmente mayor en músculos masticadores. Conclusión: La dibucaína inhibe a la SERCA de pterigoideo interno a concen-traciones menores que las usadas en clínica médica (29 mM). Es un anestésico local con potencial efecto miotóxico derivado de la inhibición de la SERCA (AU)

Aim: To test the effect of the local anesthetic dibu-caine on the main isoforms of the SERCA (sarco-endosplasmic reticulum calcium-ATPase) in medial pterygoid muscle. Methods: Sarcoplasmic reticulum membranes from male New Zealand rabbits (n=5) were isolated from medial pterygoid muscle by ul-tracentrifugation. The isoforms SERCA1a, 2a and 2b were separated using high affinity chromatography. In vitro enzymatic activity determinations were per-formed in the presence of different dibucaine con-centrations (0-90 mM) using the colorimetric method described by Fiske & Subbarow. Five assays in dupli-cate and run in parallel were performed for each of the isoforms. Mean and SEM of the IC50 (mM) for the effect of the anesthetic on each isoform were calcu-lated and compared by one-way ANOVA (p<0.05), and Student-Newman-Keuls multiple comparisons test. Results: Dibucaine inhibited the enzymatic activity in a concentration-dependent manner for the three studied isoforms. The IC50 values were: SERCA1a 20.02 ± 0.64 mM, SERCA2a 15.03 ± 0.52 mM and SER-CA2b 16.00 ± 0.51 mM. The values were significantly different (F2.27 = 11.08, p<0.001). The post hoc test revealed significant differences between SERCA1a and 2a, 1a and 2b. The inhibitory effect was signifi-cantly higher on 2a and 2b isoforms, whose presence is substantially higher in masticatory muscles. Con-clusion: Dibucaine inhibits SERCA in medial pterygoid muscle at concentrations lower than those used in clinical medicine (29 mM). It is a potentially myotoxic local anesthetic whose toxic effect may derive from SERCA inhibition (AU)

Asociación de hemangioma en zona cérvico facial y hemangioma subglótico en un neonato / Association of cervical-facial and subglottic hemangioma in neonates / Associação de hemangioma cervicofacial e subglótico em neonatos

Se presenta un neonato con hemangioma cérvico facial y posterior diagnóstico de hemangioma subglótico. Los hemangiomas en el período neonatal y los primeros meses de vida requieren una atención cuidadosa. Debido a su patrón de crecimiento y la futura aparición de nuevas lesiones, son considerados imprevisibles en esta etapa. Se encontró una fuerte asociación entre los hemangiomas difusos de localización cérvico facial y los hemangiomas sintomáticos de la vía aérea alta. El riesgo está relacionado con el grado de extensión de la afectación cutánea en un área que incluye la piel de la región mandibular, el mentón, el labio inferior y la parte anterior del cuello. Los hemangiomas infantiles requieren tratamiento cuando presentan riesgo vital y alteraciones funcionales, como compromiso de la vía aérea.

This is the case of a newborn with cervical hemangioma and a subsequent diagnosis of subglottic hemangioma. Hemangiomas in neonates and infants require careful attention. Due to their growth pattern and the potential appearance of new lesions, they are considered unpredictable at this stage. A strong link was found between diffuse cervical-facial and symptomatic upper airway hemangiomas. The risk is related to the extent of skin involvement in a given area, which might include the jaw, chin, lower lip, and front of the neck skin. Infant hemangiomas require treatment when they present life-threatening and functional alterations, such as airway compromise.

Relatamos o caso de um recém-nascido com hemangioma cervical com diagnóstico posterior de hemangioma subglótico. Hemangiomas em recém-nascidos e lactentes requerem atenção cuidadosa. Devido ao seu padrão de crescimento e ao potencial aparecimento de novas lesões, são considerados imprevisíveis nessa fase. Uma forte associação foi encontrada entre hemangiomas cervicofaciais difusos e hemangiomas sintomáticos das vias aéreas superiores. O risco está relacionado à extensão do envolvimento da pele da mandíbula, o queixo, o lábio inferior e a pele da frente do pescoço. Os hemangiomas infantis necessitam de tratamento quando apresentam alterações funcionais ou risco de vida, como comprometimento das vias aéreas.

Brachiocephalic Vein and Superior Vena Cava Reconstruction with a Superficial Femoral Vein Graft

Abstract Superior vena cava syndrome (SVCS) is an entity that has become more frequent due to the increasing use of indwelling central venous catheters. Surgical management is considered in patients with extensive venous thrombosis and when endovascular therapy is not feasible. The use of superficial femoral vein is an excellent technique for reconstruction of the brachiocephalic vein and superior vena cava (SVC) in cases with benign and malignant etiologies. We describe two cases of SVCS that were managed surgically at our institution with replacement of the SVC and brachiocephalic veins with a superficial femoral vein graft technique.

Catarata bilateral congénita en recién nacido con síndrome de Down / Congenital bilateral cataract in a newborn with Down syndrome / Catarata congênita bilateral em recém-nascido com síndrome de Down

Las cataratas son una causa importante de discapacidad visual en la población pediátrica en todo el mundo y pueden afectar significativamente el neurodesarrollo de un niño. Constituyen un problema fundamental en cuanto a su manejo y una de las causas más relevantes de ceguera tratable en los países desarrollados y en vías de desarrollo. La trisomía 21 es la cromosomopatía más frecuente, de características fenotípicas determinadas con un 60% de anormalidades oculares, entre las que se destacan las ametropías, queratocono y las cataratas. El diagnóstico clínico y la identificación temprana del tipo de cataratas, junto con intervenciones clínicas y tratamientos precoces, son claves para lograr resultados óptimos. Se presenta el caso de un recién nacido con síndrome de Down y catarata congénita bilateral y su manejo inicial.

Cataracts are a major cause of visual impairment in the pediatric population worldwide and can significantly affect a child's neurobiological development. Congenital cataract management can become a very important problem and is one of the most important causes of blindness in developed and developing countries. Trisomy 21 is the most common chromosomal disease and it has certain phenotypic characteristics and 60% ophthalmic abnormalities, such as, ametropia, keratoconus and cataracts. The diagnosis is fundamentally clinical. Early identification, diagnosis, and appropriate clinical care are key to achieve optimal results. We present the case of a newborn with Down syndrome who was diagnosed with an early bilateral congenital cataract.

A catarata é uma das principais causas de deficiência visual na população pediátrica no mundo e pode afetar significativamente o neurodesenvolvimento de uma criança, além de constituir um problema fundamental em termos de sua gestão e é uma das causas mais relevantes de cegueira tratável em países desenvolvidos e em desenvolvimento. Trissomia 21 é a cromossomopatia mais frequente e tem determinadas características fenotípicas com 60% de alterações oculares, como a ametropia, ceratocone e catarata. O diagnóstico clínico e a identificação precoce do tipo de catarata, juntamente com intervenções clínicas e tratamento precoces, são fundamentais para alcançar os melhores resultados. Apresentamos o caso de um recém-nascido com síndrome de Down e catarata congênita bilateral e seu manejo inicial.

Reumatólogos frente al papeleo: evaluación de la carga administrativa en un Servicio de Reumatología / Rheumatologists versus paperwork: assessment of administrative burden in a Rheumatology Service

Introducción: los resúmenes de historia clínica (RHC), confeccionados por reumatólogos, los solicitan los pacientes para realizar diversos trámites. Su incumplimiento afecta el acceso a las prestaciones sanitarias e implica que los médicos destinen tiempo a un requisito puramente burocrático. Los objetivos de este estudio fueron: determinar la frecuencia de RHC solicitados y realizados en nuestro Servicio durante un semestre y el tiempo dedicado a dicha tarea; describir los motivos de las solicitudes y las características de los solicitantes. Materiales y métodos: se incluyeron todos los pacientes que solicitaron ≥1 RHC en el último semestre de 2019. Se registraron características sociodemográficas, enfermedad de base y motivos de solicitud. Se consideró, como parámetro de comparación, una duración predeterminada de 15 minutos por consulta médica. Resultados: se registraron 103 solicitantes de RHC en 3159 citas programadas en 152 días. Se realizaron 144 RHC (0,95/día). Un 18% solicitó uno nuevo en el mismo intervalo. El tiempo promedio para la confección de cada resumen fue de 75 minutos. El tiempo total dedicado a estas tareas administrativas en el semestre evaluado fue el equivalente a 720 citas potenciales, aproximadamente un 20% de los turnos programados ofrecidos. La mayoría se emitió para solicitar medicamentos crónicos, principalmente para artritis reumatoidea, y con cobertura médica pública. Conclusiones: el tiempo destinado a confeccionar RHC por motivos administrativos fue el equivalente a un aumento potencial de más del 20% de las citas médicas.

Introduction: medical history summaries (MHS) issued by rheumatologists are requested by patients for various procedures. Not completing them denies access to health benefits, this implies that physicians spend time on a purely bureaucratic requirement. The objectives were: to determine the frequency of MHS requested and issued in our service during a semester and the time dedicated to them; to describe the reasons for the request and the characteristics of the applicants. Materials and methods: all patients who request ≥1 MHS in the last semester of 2019 were included. Sociodemographic characteristics, underlying disease and reasons for request were recorded. As a comparison measure, a predetermined duration of 15 minutes per medical appointment was expected. Results: 103 MHS applicants in 3159 scheduled appointments in 152 days. 144 MHS were performed (0.95/day). 18% requested a new one in the same interval. The average time in the preparation of a MHS was 75 minutes. The total time spent on these during the evaluated semester was equivalent to 720 potential appointments, approximately 20% of scheduled appointments that were granted. Most were issued to request chronic medications, mainly in rheumatoid arthritis and public health care. Conclusions: the time spent to prepare MHS for administrative reasons was comparable to a potential increase of more than 20% in medical appointments.

Impacto de la pandemia por SARS-CoV-2 en la formación de los alumnos de la Carrera de Médico Especialista en Reumatología / Impact of the SARS-CoV-2 pandemic on a group of Rheumatology trainees of Argentina

Introducción: en 2020, la rápida evolución de la pandemia por SARS-CoV-2 desencadenó una emergencia sanitaria que generó una importante reorganización del sistema de salud, lo que llevó a la discontinuación y posterior adecuación de los sistemas de formación. El objetivo de este estudio fue describir el impacto de la pandemia en un grupo de reumatólogos en formación en la Ciudad Autónoma de Buenos Aires. Materiales y métodos: se envió una encuesta online por correo electrónico a los alumnos de la Carrera de Especialista en Reumatología de la Sociedad Argentina de Reumatología y de la Universidad de Buenos Aires. Incluyó 24 preguntas relacionadas con el impacto de la pandemia en diferentes aspectos de la formación y las nuevas estrategias educativas implementadas. Resultados: de 114 alumnos contactados, respondieron 79 (69,3%). Aproximadamente el 90% indicó que su formación se afectó. Un 46% consideró que la práctica médica y la actividad académica se comprometieron por igual y el 45% solo la práctica médica. Un 50% realizó tareas no relacionadas con su formación. El 57% suspendió temporalmente la asistencia a su centro. También informaron una reducción del 55% (DE 18,6) de las actividades relacionadas con la consulta. Conclusiones: la pandemia por SARS-CoV-2 afectó a los estudiantes de Reumatología al limitar sus actividades prácticas y académicas, y por deber realizar tareas ajenas a su formación en más de la mitad de los casos.

Introduction: in 2020, the rapid evolution of the SARS-CoV-2 pandemic triggered a health emergency, generating an important heath system reorganization which led to the discontinuation and subsequent adaptation of training systems. The objective was to describe the pandemic impact on a group of rheumatology trainees in Buenos Aires, Argentina. Materials and methods: an online survey was sent through e-mail to rheumatology specialist course trainees of Argentine Society of Rheumatology and University of Buenos Aires. It included 24 close-ended questions about the pandemic impact on different aspects of rheumatology training and the new implemented educational response strategies. Results: from 114 trainees contacted, 79 (69.3%) responded. Approximately 90% indicated that their rheumatology training was affected. Forty-six percent thought that medical practice and academic activity were equally affected and 45% that only medical practice was compromised. About 50% reported that they had to perform tasks unrelated to their training. Fifty-seven percent discontinued temporarily the training site attendance. Participants reported a mean reduction of 55% (SD 18.6) of activities related to patient care. Conclusions: the SARS-CoV-2 pandemic affected rheumatology trainees, by limiting their practical and academics activities, and having to perform tasks unrelated to their training in more than a half.

Gestão do SUS em regiões interestaduais de saúde: análise da capacidade de governo / SUS management in interstate health regions: assessment of the government's capacity

Resumo Esta pesquisa apresenta uma análise da gestão do SUS em região interestadual de saúde brasileira. Realizou-se um estudo avaliativo com níveis de análise regional e produção de dados, combinando entrevistas com informantes-chave e análise documental. Cotejaram-se fontes e dados com as categorias analíticas do Triângulo de Governo, apresentando um recorte dos resultados e da análise da capacidade de governo. Há baixa capacidade de governo de regiões interestaduais de saúde quando os gestores e espaços de cogestão têm não conseguem influenciar as decisões políticas regionais, limitando-se a estratégias de governo normativas e homologatórias. Assimetrias na capacidade de gestão entre os estados da fronteira impedem a sustentabilidade de articulação das agendas decisórias estaduais, revelando que as estratégias de gestão são insuficientes para institucionalizar a regionalização interestadual. Predomina baixa capacidade de governo do SUS em regiões interestaduais de saúde, e seu desenho político tende a se tornar projeto incerto e restrito ao plano ideológico. A ampla apreciação documental com uso de potente referencial teórico são contribuições metodológicas deste estudo para análise política da gestão do SUS em espaços pouco investigados, como as fronteiras interestaduais.

Abstract This study displays an assessment of SUS management in a Brazilian interstate health region. An evaluative study was conducted with levels of regional analysis and data production, combining interviews with key informants and documentary analysis. Sources and data were compared and linked to analytical categories of the Government Triangle, showing a cutout of the outcomes and the government's capacity assessment. There is a low capacity for government in interstate health regions when managers and co-management spaces are unable to influence regional political decisions, limiting themselves to normative and ratifying government strategies. Disparities in the management capacity among the border states prevent the sustainability of coordinating state decision-making goals, exposing that management strategies are not enough to institutionalize interstate regionalization. There is a predominance of low SUS governance capacity in interstate health regions, and its political pattern becomes an unclear project restricted to the ideological level. The broad documentary appreciation with the use of powerful theoretical referential are methodological contributions of this research for the political analysis of SUS management in spaces that were the least examined, such as interstate borders.

Impact of lifestyle in prostate cancer patients. What should we do?

ABSTRACT Objective: This review aimed to analyze interventions raised within primary and tertiary prevention concerning the disease's incidence, progression, and recurrence of Prostate Cancer (PCa). Priority was given to the multidisciplinary approach of PCa patients with an emphasis on modifiable risk factors. Materials and Methods: We conducted a comprehensive literature review in the following databases: Embase, Central, and Medline. We included the most recent evidence assessing cohort studies, case-control studies, clinical trials, and systematic reviews published in the last five years. We only included studies in adults and in vitro or cell culture studies. The review was limited to English and Spanish articles. Results: Preventive interventions at all levels are the cornerstone of adherence to disease treatment and progression avoidance. The relationship in terms of healthy lifestyles is related to greater survival. The risk of developing cancer is associated to different eating habits, determined by geographic variations, possibly related to different genetic susceptibilities. Discussion: PCa is the second most common cancer in men, representing a leading cause of death among men in Latin America. Prevention strategies and healthy lifestyles are associated with higher survival rates in PCa patients. Also, screening for anxiety and the presence of symptoms related to mood disorders is essential in the patient's follow-up concerning their perception of the condition.

Contribuições da Terapia Cognitivo-Comportamental no treinamento parental de crianças com Transtorno de Oposição Desafiante / Contributions of Cognitive-Behavioral Therapy in parental training of children with Oppositional Defiant Disorder

O Transtorno de Oposição Desafiante (TOD) caracteriza-se por um padrão frequente e persistente, de humor irritável, comportamento desafiador ou índole vingativa. Diferentes estratégias de prevenção e tratamento são propostas, como é o caso do treinamento parental. Nesse contexto, destacam-se as intervenções baseadas na Terapia Cognitivo-Comportamental (TCC), as quais, apesar de apresentarem resultados promissores, ainda carecem de sistematização de suas contribuições em contexto brasileiro. Em função disso, este estudo teve como objetivo apresentar as contribuições da TCC no Treinamento de Pais de crianças com TOD. Para tanto, foi realizada uma revisão narrativa literatura. Os resultados apontaram que o treinamento parental baseado na TCC faz uso de distintas variáveis (ex. estilos ou práticas parentais, estresse e competência parental) e estratégias (ex: role-play, resolução de problemas, treino de habilidades sociais educativas e reestruturação cognitiva). Conclui-se que o TOD e seu sintomas trazem consequências negativas no contexto familiar e o treinamento parental é um recurso eficaz para prevenção e tratamento desse transtorno, uma vez que possibilita a melhoria da relação entre pais e filhos. Entretanto, estudos acerca do tema ainda precisam ser ampliados em contexto brasileiro.(AU)

The Oppositional Defiant Disorder (ODD) is characterized by a frequent and persistent pattern of irritable mood, defiant behavior or vengeful nature. Different strategies of prevention and treatment are proposed, as is the case of parental training. In this context, the interventions based on Cognitive-Behavioral Therapy (CBT) stand out, which, despite presenting promising results, still need to systematize their contributions in the brazilian context. As a result, this study aimed to present the contributions of CBT in Parents' Training of children with ODD. For this, a literature review was performed. The results showed that parental training based on Cognitive-Behavioral Therapy makes use of different variables (e.g., parenting styles or practices, stress and parental competence) and strategies (e.g., role-play, problem solving, training of educational social skills and cognitive restructuring). It is concluded that ODD and its symptoms bring negative consequences in the family context and parental training is an effective resource for prevention and treatment of this disorder, since it allows the improvement of the relationship between parents and children. However, it is suggested that studies on the subject be expanded in the brazilian context.(AU)

El trastorno de oposición desafiante (TOD) se caracteriza por un patrón frecuente y persistente de estado de ánimo irritable, comportamento desafiante o la naturaleza vengativa. Se proponen diferentes estrategias de prevención y tratamiento, como el entrenamiento de los padres. En este contexto, destacamos las intervenciones basadas en la Terapia Cognitivo-Conductual (TCC), que, a pesar de presentar resultados prometedores, todavía carecen de sistematización de sus contribuciones en el contexto brasileño. Como resultado, este estudio tenía como objetivo presentar las contribuciones de cbt en el entrenamiento de los padres de los niños con OD. Para ello, se llevó a cabo una revisión narrativa literaria. Los resultados mostraron que el entrenamiento de los padres basado en la TCC hace uso de diferentes variables (por ejemplo, estilos o prácticas de crianza, estrés y competencia parental) y estrategias (por ejemplo, juego de roles, resolución de problemas, entrenamiento de habilidades sociales educativas y reestructuración cognitiva). Se concluye que el TOD y sus síntomas traen consecuencias negativas en el contexto familiar y el entrenamiento parental es un recurso eficaz para la prevención y tratamiento de este trastorno, ya que permite la mejora de la relación entre padres e hijos. Sin embargo, se sugiere ampliar los estudios sobre el tema en el contexto brasileño.(AU)

Demora en el inicio del tratamiento biológico o sintético dirigido en pacientes con artritis reumatoidea y factores asociados a la misma / Delayed onset of biologic or targeted synthetic dmards in rheumatoid arthritis patients and associated factors

Introducción: el objetivo del tratamiento de la artritis reumatoidea (AR) es la remisión o baja actividad de la enfermedad. En aquellos pacientes que no logran dicho objetivo con drogas modificadoras de la enfermedad sintéticas convencionales (DMARsc), se indican los agentes biológicos (DMARb) o sintéticos dirigidos (DMARsd). El intervalo de tiempo entre la indicación y hasta que el paciente recibe la primera dosis es variable. Objetivos: describir el tiempo de demora y los motivos relacionados entre la indicación de DMARb o DMARsd y la administración de la primera dosis. Materiales y métodos: estudio observacional, analítico, retrospectivo. Se revisaron historias clínicas de pacientes con diagnóstico de AR, a quienes se les indicó DMARb o DMARsd. Se registraron datos sociodemográficos y características de la enfermedad. Respecto de la indicación de DMARb o DMARsd, se consignó: fecha de indicación, fecha en que el paciente recibió la primera dosis en forma efectiva y motivo de la demora. Resultados: se incluyeron 102 pacientes. La mediana de demora desde la indicación de la droga hasta que el paciente recibió la primera dosis fue de 240 días (RIC 113-504). El principal motivo de demora fue de índole burocrática (47%). Los pacientes con baja actividad de la enfermedad obtuvieron la medicación en menor tiempo (113 días) respecto de aquellos con actividad moderada (242 días) y alta actividad (332 días); p=0,01. Los pacientes en los cuales la demora fue por causas burocráticas, presentaron menor nivel de educación (60% vs 17% con educación superior) y residencia en la Provincia de Buenos Aires (58% vs 31% con residencia en la Ciudad Autónoma de Buenos Aires), siendo estas asociaciones estadísticamente significativas. Conclusiones: la mediana en la demora para el inicio de DMARb o DMARsd fue de aproximadamente 8 meses. El motivo principal de este retraso fue de índole burocrática, evidenciándose la misma con mayor frecuencia en aquellos con menor nivel educativo y en los residentes en la Provincia de Buenos Aires.

Introduction: the goal of rheumatoid arthritis (RA) treatment is to obtain remission or low activity of the disease. In those patients who did not achieve this objective with conventional treatment, biologic or targeted synthetic disease-modifying antirheumatic drugs (bDMARD or tsDMARD, respectively) are indicated. The period of time between the prescription of these medications and its administration is variable. Objectives: to describe the delay time between the prescription of a bDMARD or tsDMARD and the administration of the first dose, and its related reasons. Materials and methods: observational, analytical, retrospective study. Medical records of patients with a diagnosis of RA who were prescribed a bDMARD or tsDMARD were reviewed. Sociodemographic data and characteristics of the disease were recorded. Regarding the indication of bDMARDs or tsDMARs, the following data was collected: prescription date, date on which the patient received the first effective dose and reason for the delay. Results: 102 patients were included. The median delay time from the drug prescription until the patient received the first dose was 240 days (IQR 113-504). The main reason for delay was of bureaucratic nature (47%). Patients with low disease activity obtained the medication with a shorter delay (113 days) compared to those with moderate activity (242 days) and high activity (332 days); p=0.01. Patients with a delay related to bureaucratic causes, presented a lower level of education (60% vs 17% with higher education) and residence in the Province of Buenos Aires (58% vs 31% with residence in Autonomous City of Buenos Aires), and these differences were statistically significant. Conclusions: the median delay time to onset of bDMARDs or tsDMARDs was approximately 8 months. The main reason for this delay was of bureaucratic nature, being more frequent in those with lower educational level and residence in the Province of Buenos Aires.

Reticulohistiocitosis multicéntrica: una gran simuladora dentro de la Reumatología / Multicentric reticulohistiocytosis: a great pretender within Rheumatology

La reticulohistiocitosis multicéntrica (RHM) es una histiocitosis de células no Langerhans, multisistémica, rara, caracterizada por afectación cutánea y articular, que poco frecuentemente afecta a otros órganos. El diagnóstico se basa en hallazgos clínicos y resultados de biopsias de piel o sinovial, sin describirse un parámetro de laboratorio específico. Realizamos una revisión de la literatura en relación a las características clínicas de esta entidad desde el punto de vista reumatológico.

Multicentric reticulohistiocytosis (MHR) is a rare, multisystem, non-Langerhans cell histiocytosis characterized by skin and joint involvement, and rarely involving other organs. Diagnosis is based on clinical findings and results of skin or synovial biopsies; a specific laboratory parameter has not been described. We conducted a review of the literature regarding the clinical characteristics of this entity from a rheumatological point of view.

Demora en el inicio del tratamiento biológico o sintético dirigido en pacientes con artritis reumatoidea y factores asociados a la misma / Delayed onset of biologic or targeted synthetic dmards in rheumatoid arthritis patients and associated factors

Introducción: el objetivo del tratamiento de la artritis reumatoidea (AR) es la remisión o baja actividad de la enfermedad. En aquellos pacientes que no logran dicho objetivo con drogas modificadoras de la enfermedad sintéticas convencionales (DMARsc), se indican los agentes biológicos (DMARb) o sintéticos dirigidos (DMARsd). El intervalo de tiempo entre la indicación y hasta que el paciente recibe la primera dosis es variable. Objetivos: describir el tiempo de demora y los motivos relacionados entre la indicación de DMARb o DMARsd y la administración de la primera dosis. Materiales y métodos: estudio observacional, analítico, retrospectivo. Se revisaron historias clínicas de pacientes con diagnóstico de AR, a quienes se les indicó DMARb o DMARsd. Se registraron datos sociodemográficos y características de la enfermedad. Respecto de la indicación de DMARb o DMARsd, se consignó: fecha de indicación, fecha en que el paciente recibió la primera dosis en forma efectiva y motivo de la demora. Resultados: se incluyeron 102 pacientes. La mediana de demora desde la indicación de la droga hasta que el paciente recibió la primera dosis fue de 240 días (RIC 113-504). El principal motivo de demora fue de índole burocrática (47%). Los pacientes con baja actividad de la enfermedad obtuvieron la medicación en menor tiempo (113 días) respecto de aquellos con actividad moderada (242 días) y alta actividad (332 días); p=0,01. Los pacientes en los cuales la demora fue por causas burocráticas, presentaron menor nivel de educación (60% vs 17% con educación superior) y residencia en la Provincia de Buenos Aires (58% vs 31% con residencia en la Ciudad Autónoma de Buenos Aires), siendo estas asociaciones estadísticamente significativas. Conclusiones: la mediana en la demora para el inicio de DMARb o DMARsd fue de aproximadamente 8 meses. El motivo principal de este retraso fue de índole burocrática, evidenciándose la misma con mayor frecuencia en aquellos con menor nivel educativo y en los residentes en la Provincia de Buenos Aires.

Introduction: the goal of rheumatoid arthritis (RA) treatment is to obtain remission or low activity of the disease. In those patients who did not achieve this objective with conventional treatment, biologic or targeted synthetic disease-modifying antirheumatic drugs (bDMARD or tsDMARD, respectively) are indicated. The period of time between the prescription of these medications and its administration is variable. Objectives: to describe the delay time between the prescription of a bDMARD or tsDMARD and the administration of the first dose, and its related reasons. Materials and methods: observational, analytical, retrospective study. Medical records of patients with a diagnosis of RA who were prescribed a bDMARD or tsDMARD were reviewed. Sociodemographic data and characteristics of the disease were recorded. Regarding the indication of bDMARDs or tsDMARs, the following data was collected: prescription date, date on which the patient received the first effective dose and reason for the delay. Results: 102 patients were included. The median delay time from the drug prescription until the patient received the first dose was 240 days (IQR 113-504). The main reason for delay was of bureaucratic nature (47%). Patients with low disease activity obtained the medication with a shorter delay (113 days) compared to those with moderate activity (242 days) and high activity (332 days); p=0.01. Patients with a delay related to bureaucratic causes, presented a lower level of education (60% vs 17% with higher education) and residence in the Province of Buenos Aires (58% vs 31% with residence in Autonomous City of Buenos Aires), and these differences were statistically significant. Conclusions: the median delay time to onset of bDMARDs or tsDMARDs was approximately 8 months. The main reason for this delay was of bureaucratic nature, being more frequent in those with lower educational level and residence in the Province of Buenos Aires.

Reticulohistiocitosis multicéntrica: una gran simuladora dentro de la Reumatología / Multicentric reticulohistiocytosis: a great pretender within Rheumatology

La reticulohistiocitosis multicéntrica (RHM) es una histiocitosis de células no Langerhans, multisistémica, rara, caracterizada por afectación cutánea y articular, que poco frecuentemente afecta a otros órganos. El diagnóstico se basa en hallazgos clínicos y resultados de biopsias de piel o sinovial, sin describirse un parámetro de laboratorio específico. Realizamos una revisión de la literatura en relación a las características clínicas de esta entidad desde el punto de vista reumatológico.

Multicentric reticulohistiocytosis (MHR) is a rare, multisystem, non-Langerhans cell histiocytosis characterized by skin and joint involvement, and rarely involving other organs. Diagnosis is based on clinical findings and results of skin or synovial biopsies; a specific laboratory parameter has not been described. We conducted a review of the literature regarding the clinical characteristics of this entity from a rheumatological point of view.

Barreiras de acesso à Atenção Primária à Saúde em municípios rurais remotos do Oeste do Pará / Access barriers to Primary Health Care in remote rural municipalities of Western Pará state, Brazil / Barreras de acceso a la Atención Primaria de Salud en municipios rurales remotos del Oeste del estado de Pará, Brasil

Resumo Analisa-se neste artigo o acesso à Atenção Primária à Saúde em municípios rurais remotos do Oeste do Pará, discutindo barreiras e desafios ante as especificidades dos territórios amazônicos. Tratou-se de estudo qualitativo em cinco municípios com lógicas espaciais distintas, assentadas em rios ou estradas. Realizaram-se 58 entrevistas com gestores, profissionais da saúde e usuários, além de visitas a unidades básicas de saúde, em 2019. A matriz de análise contemplou: acessibilidade geográfica, acessibilidade organizacional, unidade básica de saúde como primeiro contato e Atenção Primária à Saúde na rede assistencial. Identificou-se que as barreiras de acesso geográfico envolvem grandes distâncias, tempos, custos, precárias condições de vias e transportes, com variação sazonal diferenciada, conforme fluxos fluviais ou terrestres. A acessibilidade organizacional é dificultada pela oferta insuficiente de consultas, exames, medicamentos, restrição nos dias de funcionamento e ações itinerantes, acentuadas pela elevada rotatividade profissional. As unidades básicas de saúde constituem-se como serviço de primeiro contato, todavia com procura condicionada à resolutividade e à satisfação percebidas, destacando-se a atuação do agente comunitário de saúde. O suporte da atenção especializada é precário, com dificuldades de oferta, regulação, transporte e comunicação. O cenário socioambiental amazônico requer estratégias singulares para oferta e organização dos serviços, refletidas em financiamento específico.

Abstract This article analyzes the access to Primary Health Care in remote rural municipalities in Western Pará state, Brazil, discussing barriers and challenges before the specificities of Amazonian territories. This was a qualitative study in five municipalities with distinct spatial logics, based on rivers or roads. There were 58 interviews with managers, health professionals, and users, as well as visits to basic health units, in 2019. The analysis matrix contemplated: geographical accessibility, organizational accessibility, primary health care unit as first contact, and Primary Health Care in the health care network. It was identified that the geographical access barriers involve great distances, times, costs, poor road conditions, and transportation, with differentiated seasonal variation, according to fluvial or terrestrial flows. Organizational accessibility is hindered by the insufficient offer of consultations, exams, medications, restrictions on the days of operation, and itinerant actions, accentuated by the high professional turnover. The basic health units are the first contact service, but the demand is conditioned to the perceived resoluteness and satisfaction, where the performance of the community health agent stands out. The support for specialized care is precarious, with difficulties in supply, regulation, transportation, and communication. The Amazon socio-environmental scenario requires unique strategies for the supply and organization of services, reflected in specific funding.

Resumen Este artículo analiza el acceso a la Atención Primaria de Salud en municipios rurales remotos del Oeste del estado de Pará, Brasil, discutiendo barreras y desafíos frente a las especificidades de los territorios amazónicos. Este fue un estudio cualitativo realizado en cinco municipios con distintas lógicas espaciales, ubicados en ríos o caminos. Se realizaron 58 entrevistas a gestores, profesionales de salud y usuarios, además de visitas a unidades básicas de salud, en 2019. La matriz de análisis incluyó: accesibilidad geográfica, accesibilidad organizacional, unidad básica de salud como primer contacto y Atención Primaria de Salud en la red asistencial. Se identificó que las barreras geográficas de acceso involucran grandes distancias, tiempos, costos, precarias condiciones de vías y transporte, con variación estacional diferenciada, según caudales fluviales o terrestres. La accesibilidad organizacional se ve obstaculizada por la insuficiente oferta de consultas, exámenes, medicamentos, restricción de jornadas y acciones itinerantes, acentuada por la alta rotación profesional. Las unidades básicas de salud son un servicio de primer contacto, sin embargo, con demanda condicionada a la resolución y a la satisfacción percibidas, destacándose el papel del agente comunitario de salud. El apoyo de la atención especializada es precario, con dificultades de oferta, regulación, transporte y comunicación. El escenario socioambiental amazónico requiere estrategias únicas para la oferta y organización de servicios, reflejadas en financiamientos específicos.

La escritura del duelo en narrativas de mujeres víctimas del conflicto colombiano / The writing of grief in narratives of women victims of the colombian conflict

El objetivo de la investigación fue comprender los efectos de la escritura autobiográfica en la elaboración de los duelos, la transformación subjetiva y la construcción de la memoria de mujeres víctimas del conflicto armado. Este artículo se concentra en lo relativo a los procesos de duelo. Método: la investigación tuvo un enfoque cualitativo y el método utilizado fue el interaccionismo simbólico; se hizo un estudio de caso con un grupo de mujeres participantes en procesos de escritura autobiográfica; la información se recolectó con entrevistas semiestructuradas, talleres de escritura y selección de textos. Resultados: la escritura auto-biográfica cumple una función positiva en el duelo de las mujeres al contribuir a procesos como: ordenar narrativamente el caos provocado por la violencia, nombrar y trabajar las pérdidas, dotar de sentidos íntimos y sociales al dolor y reconstruir las relaciones con lo perdido, con el mundo y consigo mismas. Conclusión: la escritura es un recurso valioso para avanzar en el duelo, a la manera de un ritual de despedida, ayuda a situar lo perdido en el ámbito de la memoria y a reconstruir la vida contando con la ausencia

The objective of the research was to understand the effects of autobiographical writing on the elaboration of grief, the subjective transformation and the construction of the memory of women victims of the armed conflict. This article focuses on the grief processes. Method: the approach was qualitative, the method was symbolic interactionism; a case study was made with a group of women participating in autobiographical writing processes; information was collected through semi-structured interviews, writing workshops and text selection. Results: Autobiographical writing plays a positive role in women's grief by contributing to processes such as: narrative order of chaos caused by violence, naming and working through losses, giving intimate and social meaning to pain, and reconstruction relationships with what was lost, with the world and with themselves. It is concluded that this kind of writing is a valuable resource to advance in mourning elaboration; in the manner of a farewell ritual it helps to situate the lost in the sphere of memory and to reconstruct life counting on absence

Revisitando definições e naturezas da intersetorialidade: um ensaio teórico / Revisiting definitions and natures of intersectoriality: a theoretical essay

Resumo Este ensaio teórico aborda definições e características centrais das ações intersetoriais para a saúde. Tem como objetivo, portanto, refletir sobre o conhecimento produzido a respeito das concepções e da natureza das ações intersetoriais para a saúde. Para a construção das análises, realizou-se uma revisão integrativa a partir de publicações referentes ao período de 2000 a 2019 identificadas nas bases de dados Lilacs, SciELO, Web of Science e Science Direct. O corpus contemplou 12 artigos, sendo analisados os aspectos relacionados com a finalidade, o propósito ou o método da ação intersetorial, sendo possível traçar similaridades e contrastes entre as definições. Diante da opacidade na construção de definições, coube situar que existe uma construção sócio-histórica dos conceitos, mas as definições provisórias expressam certo borramento ou apagamento que se encontram em disputa no interior do campo da saúde e que podem direcionar a distintos pontos de vista e constituir barreiras para incluir a implementação das ações intersetoriais relacionadas à promoção da saúde nas práticas cotidianas. De tais reflexões derivaram um conjunto de proposições acerca das naturezas das ações intersetoriais para a saúde, com vistas a contribuir para o debate sobre a temática.

Abstract This theoretical essay addresses definitions and central characteristics of intersectoral actions for health. It aims, therefore, to reflect on the knowledge produced about the conceptions and nature of health intersectoral actions. An integrative review was conducted for the construction of the analyses from publications referring to the 2000-2019 period identified in the Lilacs, SciELO, Web of Science, and Science Direct databases. The corpus included 12 papers, with aspects related to the aim, purpose or method of intersectoral action under analysis, outlining similarities and contrasts between definitions. Given the opacity in the construction of definitions, we had to point out a socio-historical construction of the concepts, and that the provisional definitions express a certain blurring or erasure in dispute within the field of health that can lead to different viewpoints and are barriers to include the implementation of intersectoral actions related to health promotion in daily practices. Such reflections derived a set of propositions about the nature of intersectoral health actions that aim to contribute to the debate on the theme.

Systemic lupus erythematosus and pregnancy: Strategies before, during and after pregnancy to improve outcomes / Lupus eritematoso sistémico y embarazo: estrategias antes, durante y después del embarazo para mejorar los desenlaces

ABSTRACT Systemic lupus erythematosus is a multisystemic autoimmune disorder that predominantly affects women in reproductive years. Pregnancy in women with SLE is still considered a high-risk condition although several strategies may improve maternal and fetal outcomes. Preconception counseling is fundamental and should include identification of risk factors for adverse pregnancy outcomes, explanation of potential maternal and obstetric complications and timely planning of pregnancy. Risk stratification must consider end-organ damage, comorbidities, disease activity and autoantibodies profile in order to implement an individual-risk pregnancy monitoring plan by a multidisciplinary team. Hydroxychloroquine and low dose aspirin have shown to lower the risk of disease flares and preeclampsia with a good safety profile, so its use during pregnancy in all SLE patients is recommended. Lupus nephritis and preeclampsia share clinical and laboratory features hindering differentiation between both entities. Novel angiogenic markers and fetal ultrasound findings could be helpful in the differential diagnosis, especially after 20 weeks of gestation. Antiphospholipid antibodies, particularly lupus anticoagulant, are closely associated with obstetric complications. Therapy with low dose aspirin and heparin, according to risk profile, may improve live birth rates. Anti-Ro/La antibodies confer risk for neonatal lupus, and therefore preventive therapy and special fetal surveillance should be instituted.

RESUMEN El lupus eritematoso sistémico es un trastorno autoinmune multisistémico que afecta primordialmente a mujeres en edad reproductiva. El embarazo en mujeres con LES aún se considera una condición de alto riesgo, a pesar de que diversas estrategias pueden mejorar los desenlaces maternos y fetales. La asesoría preconcepción es fundamental, y debe incluir la identificación de factores de riesgo de desenlaces adversos del embarazo, una explicación de las posibles complicaciones maternas y obstétricas, así como la planificación oportuna del embarazo. La estratificación de riesgos debe considerar el daño orgánico terminal, las comorbilidades, la actividad de la enfermedad y el perfil de autoanticuerpos, a fin de llevar a cabo un plan de monitoreo de los riesgos individuales del embarazo por parte de un equipo multidisciplinario. La hidroxicloroquina y la aspirina a bajas dosis han demostrado reducir el riesgo de exacerbaciones de la enfermedad y de preeclampsia, con un buen perfil de seguridad, por lo cual se recomienda su uso en todas las pacientes con LES durante el embarazo. La nefritis lúpica y la preeclampsia comparten características clínicas y de laboratorio, obstaculizando la diferenciación entre las 2 entidades. Nuevos marcadores angiogénicos y hallazgos ecográficos fetales pudieran ser de utilidad para el diagnóstico diferencial, especialmente después de las 20 semanas de gestación. Los anticuerpos antifosfolípidos, en particular el anticoagulante lúpico, tiene una estrecha asociación con las complicaciones obstétricas. El tratamiento con aspirina a bajas dosis y heparina, según el perfil de riesgos, puede mejorar las tasas de nacimientos vivos. Los anticuerpos anti-Ro/La representan un riesgo de lupus neonatal, por lo cual debe instituirse tratamiento preventivo y vigilancia fetal especial.

A contribuição da Atenção Primária à Saúde na rede SUS de enfrentamento à Covid-19 / The contribution of Primary Health Care in the SUS network to face Covid-19

RESUMO A centralidade no cuidado individual a casos graves descurou a abordagem populacional comunitária necessária ao enfrentamento da pandemia de Covid-19 no Sistema Único de Saúde (SUS). Neste ensaio, argumenta-se que a Estratégia Saúde da Família (ESF), com suas equipes multiprofissionais e enfoque comunitário e territorial, tem potencial para atuar na abordagem comunitária necessária ao enfrentamento da epidemia. A partir de experiências locais e internacionais, analisa quatro campos de atuação da Atenção Primária à Saúde (APS) no SUS no enfrentamento da Covid-19: vigilância nos territórios; cuidado individual dos casos confirmados e suspeitos de Covid-19; ação comunitária de apoio aos grupos vulneráveis; e continuidade dos cuidados rotineiros da APS. Reconhecem-se limites dessa atuação decorrentes de mudanças recentes na Política Nacional de Atenção Básica que afetam o modelo assistencial da vigilância em saúde. Conclui-se ser necessário ativar os atributos comunitários das equipes multiprofissionais da ESF e do Núcleo de Apoio à Saúde da Família; associar-se às iniciativas solidárias das organizações comunitárias e articular-se intersetorialmente; e garantir a continuidade das ações de promoção, prevenção e cuidado, criando novos processos de trabalho na vigilância em saúde, no apoio social e sanitário aos grupos vulneráveis e na continuidade da atenção rotineira para quem dela precisa.

ABSTRACT The focus on individual care for severe cases neglected the community-centered approach required to cope with the Covid-19 pandemic in the Unified Health System (SUS) in Brazil. This essay argues that the Family Health Strategy (ESF), by means of its multi-professional teams and community and territorial orientation, is able to successfully develop the community approach required to deal with the pandemic. Inspired by local and international experiences, this essay analyzes four dimensions regarding SUS' Primary Health Care (PHC) work in the fighting against Covid-19: community-based health surveillance, individual care for confirmed and suspected cases of Covid-19, community mobilization to support vulnerable local groups, and continuity of APS care routine. Limitations are acknowledged due to recent changes in the National Policy of Primary Health Care impacting health surveillance care model. The conclusion if for the need to: strengthen the community attributes of APS and Family Health Support multi-professional teams; collaborate with community organizations in initiatives of solidarity and articulate in an intersectoral way; guarantee the ongoing promotion, prevention and care actions by creating new working processes for health surveillance, social and health support for vulnerable groups, and for the continuity of the routine care for those in need.